GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6479891 | 1 | rs61853635 | chr10:65276510 | NRBF2 | chr10:64893007-64914785:+ | 0.27 | 4.42 | 1.2E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6480314 | 1 | rs61854764 | chr10:69965475 | PBLD | chr10:70042417-70092684:- | 0.3 | 4 | 7.41E-5 | Optic nerve measurement (disc area) |
| THCA | cis | rs6479891 | 1 | rs61855465 | chr10:64956607 | LOC84989 | chr10:65224989-65226320:+ | 0.27 | 4.38 | 1.44E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61855465 | chr10:64956607 | NRBF2 | chr10:64893007-64914785:+ | 0.28 | 4.68 | 3.68E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs7474896 | 1 | rs61857913 | chr10:37923705 | LOC399744 | chr10:38717074-38741080:+ | 0.24 | 3.34 | 0.000897 | Obesity (extreme) |
| THCA | cis | rs7474896 | 1 | rs61858625 | chr10:38002042 | LOC399744 | chr10:38717074-38741080:+ | 0.26 | 3.48 | 0.000544 | Obesity (extreme) |
| THCA | cis | rs7474896 | 1 | rs61858629 | chr10:38014770 | LOC399744 | chr10:38717074-38741080:+ | 0.28 | 3.87 | 0.000123 | Obesity (extreme) |
| THCA | cis | rs7474896 | 1 | rs61858886 | chr10:38360701 | LOC399744 | chr10:38717074-38741080:+ | 0.25 | 3.36 | 0.000856 | Obesity (extreme) |
| THCA | cis | rs7474896 | 1 | rs61859667 | chr10:38016379 | LOC399744 | chr10:38717074-38741080:+ | 0.28 | 3.67 | 0.000274 | Obesity (extreme) |
| THCA | cis | rs7078219 | 1 | rs61872688 | chr10:101273546 | NKX2-3 | chr10:101292690-101296278:+ | -0.31 | -5.56 | 4.6E-8 | Dental caries |
| THCA | cis | rs10540 | 1 | rs61876333 | chr11:487136 | IRF7 | chr11:612556-615999:- | 0.25 | 3.63 | 0.00031 | Body mass index |
| THCA | cis | rs10540 | 1 | rs61877775 | chr11:521462 | ANO9 | chr11:417930-442011:- | 0.29 | 3.54 | 0.000433 | Body mass index |
| THCA | cis | rs11026412 | 1 | rs61879300 | chr11:22117880 | ANO5 | chr11:22214722-22304913:+ | 0.35 | 6.55 | 1.49E-10 | Parkinson's disease |
| THCA | cis | rs3750965 | 1 | rs61881024 | chr11:68837794 | TPCN2 | chr11:68816350-68929907:+ | -0.16 | -4.02 | 6.66E-5 | Hair color |
| THCA | cis | rs7951870 | 1 | rs61882678 | chr11:46368241 | PACSIN3 | chr11:47199085-47207958:- | 0.18 | 3.96 | 8.8E-5 | Schizophrenia |